First-half strikes from Spinazzola and Rrahmani secured a 2-0 triumph for the visitors at the Stadio Olimpico in a match overshadowed by three dismissals.
The win propels Napoli to just one point behind of Serie A pace-setters Milan, who won on Friday. Inter occupy third place but have a chance to go back to the summit with a victory in their later match.
Despite missing a number of injured players, the southern Italian side commanded the game with patient build-up play. The first goal came when Matteo Politano's cross was volleyed home by Spinazzola at the back post.
The advantage was doubled in the 32nd minute as the defender guided a glancing header from another Politano free-kick into the bottom corner. Napoli went close to a third goal shortly after when Elmas saw his header crash against the woodwork.
After the break saw more worry for the visitors when a winger was forced off. The stoppage sparked a short confrontation, resulting in bookings for a Napoli defender and the home side's Tijjani Noslin—who subsequently was shown a second caution for a challenge.
"I must congratulate my players, playing with this level of quality and intensity while preventing Lazio have control is not easy," remarked the triumphant manager. "Our performance was at a very high level of play."
Tempers flared again near the end as two opponents became involved in a fierce confrontation, prompting the coach to intervene. The two players were dismissed for their involvement in the incident.
Over in La Liga, Sevilla suffered a heavy loss at home to lowly Levante. The visitors took control with a fine team goal before scoring two more goals in the second period to seal a convincing victory.
In other news, Real Madrid host major must-win when they welcome Real Betis, after their arch-rivals increased their lead at the top. Later on late game, Atlético Madrid travel to face La Real.
In France, a historic Parisian clasico takes place as the newly-promoted side visit giants Paris Saint-Germain. This match marks the inaugural top-flight encounter between the neighbors in decades, bringing extra intrigue to the weekend's action.
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